In 2024, the national surveillance system for infections associated with invasive devices provides representative coverage of the country, with 625 participating facilities spread across the 17 regions, accounting for 40.3% of the country’s university hospitals, general hospitals, cancer care centers, specialized cancer care centers, hospital-based care facilities, and outpatient care facilities. Surveillance is implemented in 276 intensive care units and covers 63.5% of intensive care beds (based on SAE 2023 data). Monitoring of the indicators of the National Strategy on central line-associated bloodstream infections shows that, for the adult sector, 70% of intensive care units, 73% of hematology units, 80% of oncology units, 66% of other medical units, and 74% of surgical units are meeting the target. Regarding bacteremias associated with short-term central venous catheters (CVCs), 89% of participating facilities are meeting the target. In 2024, among the 9,161 documented healthcare-associated bacteremias, 1,191 involved intensive care patients (13.0%). In total, 2,814 bacteremias were catheter-related (30.7%), of which 22.4% were associated with a PICC and 5.9% with a midline catheter. Since 2020, catheter-related bacteremias have evolved, with an increasing proportion of cases linked to PICC lines or midline catheters. This trend is particularly evident in hematology units, medical units (excluding onco-hematology), and surgical units. In adult intensive care units, the characteristics of monitored patients (2,754 in 2024) and infected patients (693 who developed catheter-related bacteremia and 175 who developed intubation-related pneumonia), the characteristics of the infections, and the incidence data, suggest a return to a situation similar to that observed before the COVID-19 pandemic. In the adult sector excluding intensive care, 1/ the incidence of central line-associated bacteremia: has been trending downward since 2021 for the stable cohort of 18 hematology departments; has remained stable for the oncology (48 departments) and intensive care (112 departments) cohorts; has tended to increase since 2022 for the stable cohorts of internal medicine (153 departments) and surgery (121 departments). 2/ The incidence of midline catheter-related bacteremias is increasing for the stable cohort of 153 internal medicine departments (excluding onco-hematology). 3/ The incidence of bacteremias related to vascular access sites for dialysis varies depending on the type of dialysis department, with a rate of 0.257 per 1,000 sessions for hemodialysis units in centers; 0.129 for medical dialysis units; and 0.071 for self-dialysis units. For neonatal intensive care units, the incidence of central line-associated bacteremia has remained stable since 2020 when considering all newborns. For the most vulnerable newborns, particularly those with a birth weight of less than 750 g, the incidence of these bacteremias has been rising since 2020 (10.112 per 100 newborns in 2020 vs. 18.248 in 2024) in line with the increase in bacteremias associated with S. haemolyticus. This trend is not observed for S. epidermidis or S. capitis. In neonatal medicine units, catheter-related bacteremias remain rare events. Since 2020, 2,117 nosocomial bacteremias acquired in long-term care facilities have been documented. Among these bacteremias, 424 were linked to an invasive device: 38 to an intravascular catheter and 386 to a recent history of urinary catheterization. Catheter-related bacteremias most often involved a PICC (40.0%) or a CCI (35.0%). Incidence data show that catheter-related bacteremias acquired in nursing homes are now rare occurrences.