The occupational disease surveillance program (MCP), conducted in the Grand Est region by Santé publique France in collaboration with the occupational health inspection unit of the DREETS Grand Est and the ORS Grand Est, relies on a network of volunteer occupational physicians and their teams who, over two consecutive weeks known as "MCP fortnights," all cases of occupational diseases observed during consultations, as well as the socio-professional characteristics of all employees seen; all of this is done confidentially. This brochure summarizes the results of the 2020 and 2021 fortnights.