The data presented here pertain to cases of active tuberculosis reported in France during 2010. The number of tuberculosis cases reported in 2010 was 5,187 (8.1 per 100,000), representing a 1.7% decrease compared to 2009 (8.2 per 100,000). As in previous years, the regions with the highest reporting rates were Île-de-France (16.3/105,000) and French Guiana (15.9/105,000). Reporting rates in all other regions were below 10 new cases per 100,000 inhabitants. Reporting rates were high (>50/105) among homeless individuals and those born abroad, particularly in countries with high tuberculosis prevalence. Tuberculosis surveillance data show a decline in reported cases in 2009 and 2010. However, the increase in case rates in a number of departments in the Île-de-France region, even if very limited, and the high rates observed in certain population groups should serve as a reminder not to relax efforts to combat tuberculosis in a context of significant disparities. (R.A.)