The purpose of this article is to provide an overview of the scientific evidence regarding validated interventions for tobacco prevention among children and adolescents. The rise in daily smoking among 17-year-olds justifies the presentation of validated interventions to promote the development of effective interventions in France. This review was conducted using a specific method for selecting and analyzing the scientific literature and classifying relevant interventions. Twenty-two interventions were identified as having an impact on youth smoking. More than half of these are aimed at the general population, while the others target vulnerable groups or young people who already smoke. Most interventions are aimed at adolescents, though some target children under 12. About half of the interventions combine multiple approaches: they can be implemented in schools, involve the family, and/or the community. A large majority of programs targeting individuals focus on the interactive development of young people’s psychosocial skills. Media campaigns, as well as larger-scale tobacco access control measures, are then presented for their effectiveness. Knowledge of these intervention methods, widely used internationally, should inform discussions on practices developed in France.[author’s abstract]