Introduction – In response to the resurgence of invasive group A streptococcal infections (IGASIs) in late 2022, healthcare professionals were encouraged to report all hospitalized IGASI cases to health authorities. The objective is to describe the cases of GAS-I reported in Auvergne-Rhône-Alpes (ARA) since 2015 and the case management measures, with a focus on the period from late 2022 to early 2023. Materials and Methods – A retrospective descriptive study was conducted using GAS-SIS reports submitted to the ARA Regional Health Agency (ARS) over two periods: “before the alert” (January 1, 2015, to December 5, 2022) and “during the alert” (December 6, 2022, to March 2, 2023). Confirmed and probable cases were defined according to the 2005 opinion of the French High Council for Public Health. Results – A total of 181 cases of IISGA were reported, 66% of which occurred during the three-month alert period. Significant differences were observed during the alert (compared to before): varied reporting sources (vs. predominantly public health officers), reduced reporting time (4.8 days vs. 7.2 days), more frequent pleuropulmonary forms (vs. gynecological and obstetric infections), and recommendations for antibiotic prophylaxis (more frequent for contacts within the same household and less frequent for contacts outside the household). Conclusion – The 2022 alert raised awareness among healthcare professionals regarding the early reporting of SISGAs, enabling the rapid implementation of management measures. This study highlights the role of the ARS in implementing and coordinating public health measures. Although reporting of IISGA is not mandatory in France, efforts toward early reporting must continue in order to implement appropriate measures, particularly in communities and/or around clusters of cases.