From January 2002 to April 2004, the Sandy Ground school complex in Saint Martin was temporarily closed four times following outbreaks of irritable syndrome among adults and children attending the schools. The recurrence of this phenomenon led the Prefect of Guadeloupe to request technical and methodological support from the Cire Antilles-Guyane. The methodology involved first synthesizing the available data from reports produced by the Guadeloupe Department of Health and Social Development and from individual interviews. A descriptive, cross-sectional, comprehensive epidemiological survey was then conducted in May 2004 among all school staff. Although recall bias was to be expected, the four episodes were documented. The results show that it is undeniable that phenomena leading to irritative-type clinical manifestations occurred within the schools of Sandy Ground. The body of information gathered suggests that the four episodes are not linked to a single cause but rather to multiple, possibly concurrent, sources. It is also likely that these phenomena were “self-amplified.” Recommendations are provided to clarify the origin of the problem. (R.A.)