This article presents results of the main measures on vaccine coverage carried out in France in children up to six years of age. Vaccine coverage is very high for diphtheria, tetanus, pertussis, and poliomyelitis, and satisfactory for vaccination against Haemophilus influenzae b invasive infections. It will be necessary, however, to increase vaccine coverage against measles, mumps and rubella in infants and to ensure efficient catch up. Hepatitis B vaccine coverage is deficient in infants and could be improved when the vaccine is available in a combined form.