BACKGROUND: Mindfulness and compassion training have individually shown significant effects on health care professionals" (HCPs') skills, reducing stress, anxiety, and burnout. This study evaluated the impact of a combined mindfulness and self-compassion intervention on HCPs" wellness. METHODS: Seventeen nurses and doctors at a teaching university hospital in France volunteered for the Mindfulness-Based Compassion and Resilience Enhancement (MBCARE) program, a four-week mindfulness and self-compassion training delivered in eight three-hour sessions over four days (one day per week), with 100% attendance. We collected primary data (mindfulness skills, burnout scores, self-compassion, and emotional coping via face-reader evaluations) before and after the intervention. RESULTS: MBCARE was associated with reduced burnout, with emotional exhaustion scores decreasing (MΔ = -4.27, t = 1.95, p = .04) and personal accomplishment scores increasing (MΔ = 2.73, z = 2.48, p = .007) among 12 health care professionals. Patient-perceived centeredness of care showed a ceiling effect, with no significant changes. In a socio-affective video task (n = 7), positive affect increased post-training (p