Today, 30 million catheters are used each year in French healthcare facilities, and nearly 30% of patients have at least one catheter in place. The use of these devices is associated with serious infections, particularly bloodstream infections. These infections are a major cause of mortality and morbidity, and the care of infected patients results in additional costs. In 2017, the national prevalence survey showed that 0.15% of patients in non-ICU wards had a central venous catheter-associated bacteremia. With the increasing use of implantable port systems and peripherally inserted central catheters, bacteremias associated with invasive devices now affect a growing number of patients outside of intensive care units. Infections associated with invasive devices are among the most preventable infections. A strategy combining infection surveillance and rapid feedback of results, monitoring of practices, and training of healthcare professionals responsible for catheter placement and handling can reduce central line-associated infections by up to 50%. Reducing the number of catheter-associated infections is a national priority enshrined in Axis 3 of the National Program for the Prevention of Healthcare-Associated Infections (PROPIAS) for the next five years. Under the authority of Santé Publique France, the National Mission for the Surveillance and Prevention of Infections Associated with Invasive Devices (SPIADI) has developed a program aimed at reducing the incidence of infections associated with invasive devices. A website dedicated to the mission was created (SPIADI.fr) and launched on December 1, 2018. The program comprises three synergistic components: infection surveillance for three months each year across all healthcare sectors, an annual campaign to observe practices, and training. During the first year of operation, the surveillance and training components were implemented. Here we report the main results and lessons learned from the first national surveillance survey of catheter-associated bacteremias, which took place from January 1 to April 30, 2019.The 2019 SPIADI surveillance protocol included 5 optional modalities: BactADI, "UNIT-BASED" surveillance of catheter-related bacteremias, recommended for all departments except intensive care; 4 “PATIENT-BASED” modalities: DIA-InfADI, surveillance of infections related to vascular access sites for hemodialysis, continuing the DIALIN surveillance; NEO-InfADI, surveillance of infections related to CVCs and CVOs and sepsis in newborns with CVCs or CVOs, continuing the NEO-Cat surveillance; REA-BactADI, surveillance in intensive care (adult and pediatric) of catheter-related bacteremia; REA-InfADI, surveillance in intensive care (adult and pediatric) of catheter-related infections and pneumonia, continuing the REA-Raisin surveillance. Surveillance was conducted over a 3-month period between January 1 and April 30, 2019. A total of 1,001 healthcare facilities participated.