In mainland France, the number of new cases of soft tissue sarcoma was estimated at 2,701 in 2018, including 1,500 in men and 1,201 in women. Key points: A cancer with an intermediate prognosis, with a 5-year net survival rate of 59% for cases diagnosed between 2010 and 2015 (in both men and women); Decrease in 5-year net survival with increasing age at diagnosis: 74% at age 30 and 47% at age 80; Among younger individuals, survival is higher in women compared to men (at age 30: 80% versus 71%, respectively), but at older ages, survival is lower in women (50% for men aged 80 versus 44% for women); Improvement in net standardized survival at 1 and 5 years of follow-up between 1990 and 2015 (+11 and +19 percentage points, respectively), with an acceleration since 2010 and a more marked improvement among older individuals; Decrease in excess mortality between 1990 and 2015, primarily during the first five years of follow-up.