In France, for the year 2018, the estimated number of new cases of multiple myeloma and plasmacytoma was 5,442, including 2,822 cases in men and 2,620 in women. Key points: Standardized 5-year net survival of 60% for people diagnosed between 2010 and 2015 (slightly higher in women); Significant difference in 5-year net survival between people aged 50 at diagnosis and those aged 80: 80% versus 42%; Improvement in 1-year and 5-year net survival between 1995 and 2015 and in 10-year survival between 1995 and 2010: +22 percentage points for 5-year survival; Survival improvement was more pronounced in the recent period and became less significant as age at diagnosis increased.