Introduction: The term “frailty” is used in geriatrics to describe the clinical consequences of the decline in a multitude of physiological functions during aging; the cumulative effect of these declines exposes older adults to an increased risk of falls, hospitalization, functional decline, and death. Studies show that frailty increases the likelihood of seeking outpatient care and the corresponding healthcare costs. Methods: Using data from the 2012 Health and Social Protection Survey supplemented with health expenditure data from the French National Health Insurance, this study analyzes medication use in terms of value (outpatient pharmacy expenditure) and volume (number of medication packages dispensed over the year) according to frailty phenotype (robust, pre-frail, frail). The analysis was conducted among 1,890 individuals aged 65 and older who received at least one medication reimbursement in 2012, taking into account their sociodemographic and health characteristics in Generalized Linear Models (GLMs). Results: On average, the pharmacy expenditure of a "frail" individual is €287 higher per year than that of a "robust" individual. For the same number of drug types, "frail" individuals are dispensed an average of 17 additional boxes of medication per year. Conclusion: This study shows that “frail” individuals have higher outpatient pharmacy expenditures than non-frail individuals and that this difference stems in part from the increased number of packages dispensed to “frail” individuals. One hypothesis that could explain this result is that physicians perceive frailty as an indicator of the severity of associated conditions.