The surveillance of healthcare-associated infections (HAIs) is a priority in intensive care, a high-risk setting due to patients’ critical condition and their exposure to invasive devices. Since 2004, the national REA-Raisin surveillance program, coordinated by the Network for Alert, Investigation, and Surveillance of HAI, has targeted infections associated with invasive devices in adult intensive care units for which a prevention strategy is essential: pneumonia (PNE), colonization, infection, or bacteremia (COL/ILC/BLC) associated with central venous catheters (CVC), and bacteremia (BAC). Each year, participating units collect data over a 6-month period on all patients hospitalized for more than 2 days (d). From January to June 2014, 212 departments included 34,226 patients (mean age: 64.3 years), hospitalized for an average of 11.6 days, of whom 68.8% were admitted to medical wards, 18.0% to emergency surgery, and 13.2% to elective surgery; 7.8% of patients were trauma patients, 15.9% were immunocompromised, and 57.0% received antibiotic treatment upon admission. The mean IGS II score was 45.3 and the in-hospital mortality rate was 17.2%. Exposure to invasive devices was common: intubation (63.8%), central venous catheter (65.3%), and urinary catheter (87.4%). Among the 34,226 patients, 10.7% developed at least one monitored infection. The most frequently isolated microorganisms were P. aeruginosa (14.8%), S. aureus (11.6%), and E. coli (9.1%). Since 2004, antibiotic resistance has been decreasing for S. aureus strains (19.2% MRSA [Methicillin-resistant Staphylococcus aureus] in 2014) and remains high for ESBL-producing Enterobacteriaceae (Extended-spectrum beta-lactamase-producing Enterobacteriaceae) (18.3% of ESBL-producing strains, with 1.6% resistant to imipenem). Incidence rates are 14.26 PNE per 1,000 intubation-days, 3.53 BAC per 1,000 hospitalization-days, 0.66 ILC, and 0.51 BLC per 1,000 CVC-days. These rates vary significantly from one department to another depending on patient characteristics. Over the past six years (2009 to 2014) across the entire network, certain risk factors have increased (age, ISC II, antibiotics on admission, immunosuppression, fewer patients undergoing elective surgery, fewer trauma patients), while the length of stay has decreased, as has the exposure ratio for intubation and urinary catheterization. There was a significant decrease in incidence rates per 1,000 days of exposure: PNE (-6.2%), BLC (-43.3%), and ILC (-40.5%), or a non-significant decrease for BAC (-1.1%). Multivariate analysis confirms the significant decrease in 2014 in PNE related to intubation (adjusted odds ratio, OR: 0.90; 95% confidence interval, 95% CI: 0.84–0.97) and BLC (adjusted OR: 0.56; 95% CI: 0.44–0.71), which can be linked to improvements in professional practices associated with invasive procedures in intensive care. With participation representing 50.4% of intensive care beds in France, the REA-Raisin data serve as a national benchmark for better understanding adverse events in intensive care and enable participating units to compare, evaluate, and guide their prevention efforts.