Reducing the incidence of surgical site infections (SSIs) is one of the objectives of the national program to combat nosocomial infections (NI). Since 1999, interregional surveillance of SSIs has been coordinated by the Network for Alert, Investigation, and Surveillance of Nosocomial Infections (Raisin). Each year, participating surgical departments collect information regarding the patient or the procedure, including the components of the NNIS risk index. All included patients were to be followed up through the 30th postoperative day. SSI cases were defined according to standard criteria. In 2010, 2,270 departments reported 304,007 surgical procedures; these figures were 1,889 and 231,851, respectively, in 2009. In 2010, more than two-thirds of the procedures included were in orthopedics (28.9%), gastrointestinal surgery (19.2%), and obstetrics and gynecology (15.2%). The incidence of surgical site infections (SSIs) was 0.96% (2,931 infections) in 2010, compared to 1% in 2009 (2,330 infections). In 2009–2010, the incidence ranged from 0.61% for low-risk patients (NNIS-0) to 9.20% for the highest-risk patients (NNIS-3). From 2006 to 2010, the overall incidence of SIS decreased by 24%. For colon surgery, the incidence decreased by 27%, for cesarean sections by 30%, for peripheral vein surgery by 34%, and for breast surgery by 5%. The number of departments with a high SSI incidence rate dropped significantly during this period. SIS monitoring is now well established in France, and the reduction in their incidence continues. The SIS rate will be one of the indicators used to evaluate the 2009–2013 national program to combat healthcare-associated infections. (R.A.)