Under the auspices of the Network for the Alert, Investigation, and Surveillance of Nosocomial Infections (Raisin) and in collaboration with the Study Group on Healthcare Workers’ Risk of Exposure to Infectious Agents (Geres), methods for monitoring blood-exposure incidents (BEIs) have been the subject of a consensus and a national network since 2002. In 2005, 13,949 blood exposure incidents were recorded in 385 facilities. The network’s national coverage can be estimated at 13% of healthcare facilities and 34% of beds, representing a slight increase compared to 2004, which confirms the broad reach of this network. The incidence of AES per 100 hospital beds is 8.8. Based on the 461,774 hospital beds recorded in France (SAE 2004 data), this allows us to estimate the number of blood exposure incidents reported in 2005 to occupational physicians at French healthcare facilities at 40,620 (95% CI: 40,243–40,998). Knowledge of the source patient’s status regarding HCV and HIV—which determines the subsequent management of the healthcare worker—remains unknown in more than 20% of cases. The rate of prescribing antiretroviral chemoprophylaxis stabilized at 4.5% in 2005 and was discontinued in 46% of cases, most often due to the subsequent discovery that the source patient was HIV-negative. The median time to care for a healthcare worker following a NSI was one hour, demonstrating the highly operational nature of this system in France. As in 2004, suture needles ranked first among needle-related NSPs, ahead of subcutaneous needles, with 1,080 NSPs and 10% of all accidents, affecting the fields of surgery, obstetrics, as well as intensive care and emergency medicine. It therefore still appears necessary to improve the safety of this procedure and to promote the use of blunt-tip needles. A comparison of the 258 facilities that participated in the surveillance in 2004 and 2005 already reveals some significant progress. Compliance with glove use among victims and the proximity of safety containers increased from 62.5% to 64.3% and from 67.3% to 69.8%, respectively, between 2004 and 2005. The incidence of AEs per 100 beds in these facilities remained stable at 8.1 in 2005 compared to 8.3 in 2004, and there was a significant increase in AEs related to vacuum-assisted blood collection systems, rising from 5.1 per 100,000 devices in 2004 to 6.8 in 2005. The consolidation of 2005 HAIs surveillance data confirms the strong establishment of this network in France and demonstrates the involvement of occupational physicians in preventing this risk. RAISIN data objectively confirm the continued improvement in adherence to standard precautions without a significant associated decrease in HAIs this year. The continued implementation of safety measures should lead to a reduction in risk in the coming years, and the national surveillance system is capable of objectively measuring this. (R.A.)