Introduction - The objective of this study, based on the first wave of the Health, Inequalities, and Social Disruptions (SIRS) cohort, is to estimate the association between certain life, family, and biographical events experienced during childhood, adolescence, or adulthood and the presence of overweight in adulthood. Methods - SIRS is a cohort consisting of 3,000 French-speaking adults in the Paris metropolitan area who were interviewed face-to-face in their homes. After adjustment and calibration using census data, this sample is representative of the reference population. Logistic regression models with overweight (self-reported body mass index = 25 kg/m²) as the variable of interest were estimated separately for men and women. Results - On the day of the survey, 36.4% of respondents reported being overweight. Men were more likely to be overweight, while women were more likely to be obese. Factors associated with a higher risk of overweight in women include: parents of African or North African descent, having children, and having experienced an unhappy childhood followed by a happy adolescence. For men, these risk factors for being overweight are: having children, and living with or having lived with a partner suffering from a serious illness. Conversely, the following are associated with a lower risk of being overweight among women: having experienced a separation or divorce, and having had a happy childhood followed by an unhappy adolescence. Among men, having experienced the death of a spouse and having had a serious illness before the age of 18 are associated with a lower risk of being overweight. Conclusion - These results suggest that certain life events may be associated with body weight status, and that these associations differ by sex. To clarify the chronological significance of these associations and better incorporate them into the prevention of overweight and obesity, further studies—ideally prospective ones—should be considered. (R.A.)