The effectiveness of early home-based prevention interventions—which offer parents activities designed to develop their psychosocial and caregiving skills—is recognized in the scientific literature, particularly for interventions targeting families with multiple medical, psychological, and social risk factors for vulnerability. However, is the quality of these interventions guaranteed? Based on a literature review, Santé publique France has identified 13 criteria likely to promote the implementation of high-quality interventions, ranging from taking into account the expectations of the target population to providing support for professionals.