Urinary concentrations of phthalate/DINCH metabolites and body mass index among European children and adolescents in the HBM4EU Aligned Studies: A cross-sectional multi-country study

Publié le 3 août 2024 Mis à jour le 4 septembre 2024

BACKGROUND: Phthalates are ubiquitous in the environment. Despite short half-lives, chronic exposure can lead to endocrine disruption. The safety of phthalate substitute DINCH is unclear. OBJECTIVE: To evaluate associations between urinary concentrations of phthalate/DINCH metabolites and body mass index (BMI) z-score among children and adolescents. METHOD: We used Human Biomonitoring for Europe Aligned Studies data from 2876 children (12 studies, 6-12 years, 2014-2021) and 2499 adolescents (10 studies, 12-18 years, 2014-2021) with up to 14 phthalate/DINCH urinary metabolites. We used multilevel linear regression to assess associations between phthalate/DINCH concentrations and BMI z-scores, testing effect modification by sex. In a subset, Bayesian kernel machine regression (BKMR) and quantile-based g-computation assessed important predictors and mixture effects. RESULTS: In children, we found few associations in single pollutant models and no interactions by sex (p-interaction > 0.1). BKMR detected no relevant exposures (posterior inclusion probabilities, PIPs

Auteur(s) : Desalegn Anteneh, Schillemans Tessa, Papadopoulou Eleni, Sakhi Amrit K, Haug Line S, Henriette Caspersen Ida, Rodriguez-Carrillo Andrea, Remy Sylvie, Schoeters Greet, Covaci Adrian, Laeremans Michelle, Fernández Mariana F, Pedraza-Diaz Susana, Kold Jensen Tina, Frederiksen Hanne, Åkesson Agneta, Cox Bianca, Cynthia D'Cruz Shereen, Rambaud Loïc, Riou Margaux, Kolossa-Gehring Marike, Gerofke Antje, Murawski Aline, Vogel Nina, Gabriel Catherine, Karakitsios Spyros, Papaioannou Nafsika, Sarigiannis Dimosthenis, Barbone Fabio, Rosolen Valentina, Lignell Sanna, Karin Lindroos Anna, Snoj Tratnik Janja, Stajnko Anja, Kosjek Tina, Tkalec Žiga, Fabelova Lucia, Palkovicova Murinova Lubica, Kolena Branislav, Wimmerova Sona, Szigeti Tamás, Középesy Szilvia, van den Brand Annick, Zock Jan-Paul, Janasik Beata, Wasowicz Wojciech, De Decker Annelies, De Henauw Stefaan, Govarts Eva, Iszatt Nina

Année de publication : 2024

Pages : 108931