BACKGROUND: Prevention and early detection of chronic kidney disease (CKD) are major public health goals to prevent and slow its progression to kidney failure. In this respect, our main objective was to estimate the prevalence of CKD (stages 1 to 5 without replacement therapy) in French adults and to study its determinants. METHODS: Constances is a population-based cohort designed as a national research infrastructure. Eligible population included participants (18-69 years) who had both isotope dilution mass spectrometry (IDMS) traceable creatinine-based estimated glomerular filration rate (eGFR) and urinary albumin-creatinine ratio measurements. Multivariable analysis was performed to assess the association between covariables of interest and CKD. RESULTS: Of the 11,429 subjects included in our sample, (48% women; mean (± standard deviation) age: 52 ± 13 years), 715 have CKD (ACR ≥ 3 mg/mmol creatinine and/or eGFR